Shorter than we thought: The duration of venture creation processes

More ties than we thought

We extend the existing enumeration of neck tie knots to include tie knots with a textured front, tied with the narrow end of a tie. These tie knots have gained popularity in recent years, based on reconstructions of a costume detail from The Matrix Reloaded, and are explicitly ruled out in the enumeration by Fink and Mao (2000). We show that the relaxed tie knot description language that compre...

The dairy fat paradox: Whole dairy products may be healthier than we thought

Phosphoinositides: Older Than We First Thought?

Despite nearly 50 years of study, it is good to see that phosphoinositides are still capable of springing the odd surprise. Signaling by the second messenger phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) was thought to be absent in yeast, but a recent paper now describes the presence of PtdIns(3,4,5)P(3) in Schizosaccharomyces pombe.

Immunodeficiency - “ Much More Common Than We Thought ”

10 years with the development of new genetic techniques more than 100 mutations in various genes were found to be associated with primary immunodeficiencies entities. It should be noted that in some diseases several hundreds of patients were found, while in others only few children were discovered, thus applying that we are dealing with rare situations. Using the same genetic techniques a new c...

The puzzle of nitrate tolerance: pieces smaller than we thought?

Nitroglycerin (GTN) and other organic nitrates are important drugs commonly used in cardiovascular medicine, and, more recently, in obstetrics as tocolytic agents.1 The development of tolerance, ie, the reduction in effect or the requirement for higher doses that appears after continuous use,2 is a major factor limiting the efficacy of these drugs. Despite their clinical importance in the thera...